Lung Health Horizons
Issue #1 (October 2025)
A curated monthly digest of the latest pioneering lung health research in English, French & Spanish
Early diagnosis and treatment of COPD and asthma - A randomized, controlled trial.
Aaron SD, Vandemheen KL, Whitmore Alex G, et al. N Engl J Med 2024;390:2061–2073. doi:10.1056/NEJMoa2401389.
Summary: A multicentre randomised controlled trial assessing whether early diagnosis and treatment of airway disease reduces healthcare utilisation. The results suggest early intervention can meaningfully reduce exacerbations and hospitalisations.
🇫🇷 Essai contrôlé randomisé multicentrique évaluant si un diagnostic et un traitement précoces des maladies des voies respiratoires réduisent le recours aux soins. Les résultats suggèrent qu’une intervention précoce peut diminuer de manière significative les exacerbations et les hospitalisations.
🇪🇸 Ensayo clínico aleatorizado multicéntrico que evalúa si un diagnóstico y tratamiento tempranos de las enfermedades de las vías respiratorias reducen la utilización de los servicios sanitarios. Los resultados sugieren que una intervención precoz puede reducir significativamente las exacerbaciones y las hospitalizaciones.
Key implications: This challenges the “wait until symptoms worsen” paradigm and supports proactive screening and treatment.
🇫🇷 Remet en question le paradigme « attendre l’aggravation des symptômes » et soutiens un dépistage et un traitement proactifs.
🇪🇸 Cuestiona el paradigma de “esperar a que los síntomas empeoren” y respalda el cribado y tratamiento proactivos.
Advances in lung cancer basic and translational research in 2025 – overview and perspectives focusing on NSCLC.
Mascaux C, Sen T, Sanchez-Cespedes M, et al. J Thorac Oncol. 2025;20(10):1369–1391. doi:10.1016/j.jtho.2025.05.024.
Summary: This overview collects the latest breakthroughs in NSCLC (non-small cell lung cancer) from basic science to translational strategies, including novel biomarkers and resistance mechanisms.
🇫🇷 Cette synthèse rassemble les dernières avancées en CPNPC (cancer du poumon non à petites cellules), de la recherche fondamentale aux approches translationnelles, incluant de nouveaux biomarqueurs et des mécanismes de résistance.
🇪🇸 Esta revisión reúne los avances más recientes en CPNM (carcinoma pulmonar no microcítico), desde la investigación básica hasta las estrategias traslacionales, incluyendo nuevos biomarcadores y mecanismos de resistencia.
Key implications: It sets the horizon for where lung cancer therapy is heading — especially for targeted therapies and immunotherapy.
🇫🇷 Trace les orientations futures des thérapies du cancer du poumon, en particulier pour les traitements ciblés et l’immunothérapie.
🇪🇸 Marca el horizonte hacia el que se dirige la terapia del cáncer de pulmón, especialmente en terapias dirigidas e inmunoterapia.
Automated diagnosis of lung diseases using vision transformer: a comparative study on chest X-ray classification.
Ahmad M, Usman S, Batyrshin I, et al. arXiv preprint 2025; arXiv:2503.18973.
Summary: This study applies Vision Transformer (ViT) and related architectures to chest X-ray classification (normal, lung opacity, pneumonia). It achieves ~99% binary accuracy and ~95% multiclass accuracy, outperforming CNN baselines.
🇫🇷 Cette étude applique les Vision Transformers (ViT) au classement radiographique thoracique et atteint ~99% de précision binaire et ~95% en multiclasses, surpassant les CNN.
🇪🇸 Este estudio aplica Vision Transformers (ViT) a la clasificación de radiografías de tórax, logrando ~99% de precisión binaria y ~95% multiclase, superando a las CNN.
Key implications: Using state-of-the-art AI architectures in chest imaging may accelerate diagnostic workflows, especially in resource-limited settings.
🇫🇷 L’IA de pointe peut accélérer les diagnostics en imagerie thoracique, notamment dans les contextes à ressources limitées.
🇪🇸 Las arquitecturas de IA de última generación pueden acelerar el diagnóstico por imagen, especialmente en entornos con recursos limitados.
Direct numerical simulations of inhalation in a 23-generation lung model.
Atzori M, Gallorini E, Cottini C, et al. arXiv preprint, 2025; https://doi.org/10.48550/arXiv.2506.14729
Summary: This work conducts high-fidelity fluid dynamics simulations across a 23-generation bronchial tree, revealing that fluctuations (not just mean flow) influence delivery deep in the lung.
🇫🇷 Des simulations numériques haute fidélité montrent que les fluctuations du flux, et non la seule moyenne, influencent la distribution profonde dans l’arbre bronchique.
🇪🇸 Simulaciones numéricas de alta fidelidad muestran que las fluctuaciones del flujo, y no solo el flujo medio, influyen en la distribución profunda en el árbol bronquial.
Key implications: It challenges simplified assumptions in inhaler/particle deposition modelling and may improve inhaled drug design.
🇫🇷 Remet en question les hypothèses simplifiées des modèles d’aérosolisation et pourrait améliorer la conception des traitements inhalés.
🇪🇸 Cuestiona los modelos simplificados de deposición y podría mejorar el diseño de terapias inhaladas.
Association of lung health and cardiovascular health (Life’s Essential 8).
Zhang W, Zou M, Liang J, et al. Front Med 2025;12. https://doi.org/10.3389/fmed.2025.1481213.
Summary: Using NHANES data (2007–2018), the authors examine how the “Life’s Essential 8” cardiovascular health metric correlates with lung disease, function, and symptoms. Higher LE8 scores are associated with lower odds of asthma and chronic bronchitis, and better FEV₁/FVC.
🇫🇷 À partir des données NHANES, les auteurs montrent qu’un meilleur score LE8 est associé à moins d’asthme et de bronchite chronique, ainsi qu’à de meilleurs paramètres fonctionnels respiratoires.
🇪🇸 Con datos de NHANES, los autores muestran que puntuaciones más altas de LE8 se asocian con menor riesgo de asma y bronquitis crónica y con mejores parámetros funcionales respiratorios.
Key implications: This underscores the integrated nature of cardiopulmonary health and suggests lung outcomes could benefit from cardiovascular health promotion.
🇫🇷 Souligne l’intégration étroite entre la santé respiratoire et cardiovasculaire, et l’intérêt d’approches préventives conjointes.
🇪🇸 Destaca la estrecha integración entre la salud respiratoria y cardiovascular y el valor de estrategias preventivas combinadas.
Breathing barriers: bridging lung health, research, and awareness.
Pott H, Sykes DL, Charriot J,∙et al. Lancet Respir Med2025;13(8):665–667. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00215-2/abstract
Summary: This commentary discusses the disconnect between respiratory research outputs and community uptake, especially in non-English speaking populations, and argues for more inclusive dissemination strategies.
🇫🇷 Ce commentaire décrit les écarts entre la production scientifique et son appropriation par les communautés, en particulier non anglophones, et plaide pour une diffusion plus inclusive.
🇪🇸 Este comentario describe la brecha entre la producción científica y su adopción por las comunidades, especialmente no angloparlantes, y aboga por una difusión más inclusiva.
Key implications: Supports the need to better connect research, translation, and the public.
🇫🇷 Soutient la nécessité de mieux relier recherche, traduction et publics afin de réduire les inégalités sanitaires.
🇪🇸 Respalda la necesidad de conectar mejor la investigación, la traducción y las comunidades para reducir desigualdades sanitarias.
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Editorial note
This series privileges pioneering or decision-relevant evidence (large RCTs, comparative-effectiveness, national cohorts, and global estimates) over incremental or repetitive reviews. Articles are selected across English, French and Spanish sources to reflect the international nature of medical research.
🌍 Why This Matters
Respiratory disease remains one of the top global causes of disability and death. Yet much of the research appears in specialised or non-English journals — making it harder for busy clinicians and policy-makers to stay informed.
Lung Health Horizons bridges that gap:
- We track major developments across three languages.
- We highlight genuinely pioneering work (not repetitive reviews).
- We translate complexity into clear, actionable summaries.
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